The Arizona Cardinals trailed the San Francisco 49ers 14-10 at one point in the second quarter.

In NFL football games, however, there are four quarters.

The 49ers won 38-10 over the Cardinals in Mexico City after scoring 24 unanswered points.

ESPN's Troy Aikman didn't mince words after the 49ers final score, a 32-yard catch and run from George Kittle on which Cardinals defenders appeared to give up.

"The Arizona Cardinals are embarrassed" Aikman said

They are a losing football team, and they are playing like one on that play, he added.

With the loss, Arizona fell to 4-7. The 49ers are now 6-4.

It's going to take a complete 180-degree turn for them to salvage the season, Aikman said of Arizona's chances moving forward.

In NFL Week 12, the Cardinals will host the Los Angeles Chargers. The San Francisco 49ers take on the New Orleans Saints.

Brandon Aiyuk had two catches for 20 yards and two touchdowns, while Kittle had four catches for 84 yards and two touchdowns.