When the Dallas Cowboys meet the Jacksonville Jaguars, who are fighting to keep their modest playoff chances alive, in Jacksonville, Florida.
They will strive to extend their four-game winning streak, seal a postseason spot, and keep themselves in the running for the NFC East championship.
The Cowboys have won four straight games, but they just managed to maintain that run last week after defeating the Houston Texans 27-23.
Dallas still has a potent offence, with Tony Pollard and Ezekiel Elliott at the helm, and plays three of its next four games away from home.
The Jaguars recently defeated the Tennessee Titans 36-22, which was their most spectacular victory of the year.
Trevor Lawrence, the quarterback, had his best game of the year, completing 30 of 42 passes for 368 yards, three touchdowns, and no interceptions.
The New England Patriots, the Los Angeles Chargers, and the New York Jets, who are tied for the last AFC Wild Card spot, are two games ahead of Jacksonville.
Dallas has a number of injuries, but its important offensive players are still there. When Dak Prescott and his receivers are in sync and the Cowboys are running the ball well, they have been explosive.
The Jaguars' 22.7 points per game defence places them marginally in the top half of the league.
The Cowboys boast one of the top defences in the NFL, but they also had the second-most sacks (48) and fewest points scored against them in the league (229).
However, Jacksonville, who averages 22.6 points per game, just put on their finest offensive display of the year in a win against Tennessee.